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Mephedrone (MEPH) is a synthetic cathinone derivative with effects that mimic MDMA and/or cocaine. Our study in male Wistar rats provides detailed investigations of MEPH’s and its primary metabolite nor-mephedrone’s (nor-MEPH) pharmacokinetics and bio-distribution to four different substrates (serum, brain, lungs, and liver), as well as comparative analysis of their effects on locomotion

Mephedrone , whose chemical formula is 4-methylmethcathinone, is a synthetic molecule derived from cathinone , the alkaloid of khat (found mainly in eastern Africa). It is a stimulant drug belonging to the family of phenylethylamines (containing among others MDMA and amphetamines).

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It is part of the flood of new drugs on sale on the internet , but its media coverage, especially in England, has boosted its consumption. Its classification on the list of narcotics on 06/12/2010 in France, then its ban on 12/3/2010 in Europe did not prevent users from continuing to take it, but above all prohibited any prevention and education about drug use. 'use.

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Ethnographic observations made in Parisian homosexual clubbing circles show the emergence of mephedrone in insider circles, gays in particular

Appearance, what does it look like?

Mephedrone is either packaged in the form of capsules or tablets, or sold in bulk as a white powder similar to cocaine. It has a distinctive licorice smell.

" For the past few months, I have seen a "new drug" swirling around me. Apparently a kind of mixture between MDMA, amphae, see coke (.... for the latter I am not convinced). It has an "ivory" color but above all, a distinctive sign, it stinks of liquorice, fennel or something like that. In short, a tenacious and recognizable smell. They call it all sorts of "nicknames", but it sounds like (or would be) "mephedrone".

Consumption patterns

Mephedrone can be consumed by ingestion, in the form of a parachute, but also smoked, snorted or injected.

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Dosage

Oral

Light effect: 50-100mg

Common effect: 100-200mg

Strong effect: 150-300mg

Very strong effect: 300mg+

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Sniff

Light effect 15-25mg

Joint effect 20-80mg

Strong effect 75-125mg

Strong effect 125mg+

The desired effects

This molecule is empathogenic (which facilitates contact), euphoric . These effects would be between those of MDMA and amphetamines.

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In parachute, the effects are felt between a quarter of an hour and an hour after taking, and lasts up to six hours. When snorted, smoked or injected, the effects are almost immediate (a few minutes for the snort, and a few seconds for the injection or the smoke). On the other hand, the effects last less long, about 3 hours.

" I tested mephedrone three weeks ago, first at an evening with friends.

7:30 p.m. I take a small parachute. After an hour I feel up the effect is stimulating pushes to drink and smoke but completely cuts the desire to eat. I resume a parachute around 11:00 p.m. do, I take a small parachute at 01:30 I am always with friends in a very stoned night bar, difficult to follow a conversation, my eyes are at war in their sockets like with MDMA, but big motivation to be with world, I end up at home at 3:00 a.m. with two strangers (hehe it makes it easier to take action; I'm usually super shy, there on the contrary, I attack, I insist and I get my way. ..) to drink glass on glass, smoking fags on fag sleep finally at 9:00 in the morning with one of them. Butin the end, appalling descent over several days, sleep disorder, guilt...

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" It can be taken in several different ways, my favorite being by parachute. The sniffer completely tears your nose off, and this kind of almond/plasticine/coconut smell sticks in your nostrils for two days. The first effects in para arrive after about a quarter of an hour. Incredible hot flashes, uncontrollable teeth grinding, a feeling of "floating" in the surrounding air, and above all this constant need to talk. What amuses me the most about this drug (when taken with people) is that little moment where everyone is uphill at the same time and the conversation makes absolutely no sense but continues. I remember once taking it all night with friends, and talking continuously until 9am. My mouth was full of canker sores because of it... I find the effect very similar to that caused by MD. Nevertheless, the descent is VERY painful, the strongest feeling (for me) being that of not wanting anything. »

The risks of consumption

Dangerousness and damage of the product according to different classifications

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The side effects

The side effects are very similar to those of amphetamines, mephedrone can cause paranoia, heart problems with risk of infarction due to local vasoconstriction.

It is very difficult to have perspective on the long-term effects and toxicity of mephedrone, for lack of serious studies.

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" with mephedrone it is the product that gave me the most intense hallucinations of my life . I had consumed 1 gram in the evening then I went to sleep, I woke up a few hours later, I smoked a bowl of hash and there I had an incredible hallus festival... »

Lowering

Many users report a painful descent , similar to that of MDMA.

" Evening in an apartment, very cool, I drink a little, about 3 glasses, then a girl from London tells us that she has drugs that she received the same morning called Miaou . She tells us it's like fake coke. In my mind, I say to myself: a legal drug ordered on the internet and the profile of the girl who really does not look like a drug user, it must be something really light, cheap, that does not do much like bio- smoke for weed..

I sniff a very big line, a big beam, telling myself that it won't do anything or at best some small effects if I take a lot, really not taking the thing seriously.... Already the product is tearing the nostrils, it burns a lot. The very strong smell is between a kind of chemical lemon and licorice. 

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I have a very very violent immediate rise, MDMA type but really totally immediate, maybe due to the high dose I took at one time. Taken by surprise, I start to panic, cold sweats, dark effect of an MD trip that starts badly, but I come back well and finally the ecsta effect lasts barely ten minutes, then turns into a speed/coke trip that lasts a good hour in my case. No sniffling but a lot of teeth grinding. Quite close to coke, this effect is not bad, with all the usual characteristics (chatterbox, euphoria etc...), and lasts longer compared to coke. 

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I feel a little better and decide to resume a small line about 1.5 hours later, but there the effect lasts less, and I quickly find myself in a down where I no longer want to talk to anyone, anxiety, attack of panic... People leave, I take 2 Xanax because I feel very anxious. I go to bed, sleep 10H, wake up about OK. I drink a coffee, eat, and, very strangely, I have a lift just after I finish eating. I become very confused mentally, I go to take a shower to try to come back down but barely in the shower I am panicked and come out of the bathroom, completely panicked.

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" I had it last week. It was ordered on a site despite the ban and I received it at my home 6 days later. I do a very small line...nothing, I do a bigger one and there I feel a strong rise but not unpleasant and it lasts...at least four hours, if not more. The effect is between coke and amphetamines but I managed to eat at night and fall asleep at midnight just taking a xanax 0.25. A very strong and rather cool experience, much less nasty than what I had read as an opinion. The big problem!! it's that when I woke up the next morning...I was still stoned!!!! This product takes a long time to eliminate from the body and I felt a little spleen for a day. »

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How to reduce the risks

Mephedrone is an illegal drug. Even when you buy it on the internet, you can't know what's inside . Always start by testing a small dose, and wait at least an hour (in ingestion) or 30 minutes (in sniff) to see what effect it has.

Mephedrone leads to a painful descent and a depressive state in the days following the intake. It is advisable not to consume again during these days, and to rest, to eat vitamin products.

You must avoid having a full or empty stomach when taking an ingestion (nausea, vomiting, etc.)

Avoid any activity requiring concentration (working on machines, driving a car, etc.) during the effect and the descent: excitement, euphoria, nervousness, even aggressiveness can lead to inappropriate behavior or inconsiderate risk-taking.

It is necessary to space out the doses of mephedrone . A break of at least 1 month should be observed between each dose, especially since the long-term effects of mephedrone are not known.

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All drugs, including mephedrone, cause a decrease in alertness which can lead to unprotected and, sometimes, unwanted sex. Always have condoms on hand . When you go out with a group of friends, watch out for each other.

It is better to consume, especially the first time, with experienced people , who will be able to guide and advise you.

" 1st take of Mephedrone, very weird feeling, unknown but not bad. Totally different from C.. The effect is really long, for me 3 hours (for 16mg) of a state completely elsewhere, as if the body were asleep, but my mind is there, but we don't control the reflexes too much. weird. My jaw clenches, my lip is so swollen from biting it, & I'm not doing it on purpose.. It is absolutely necessary that the grip be made in the company of someone I trust. Psk since it was the 1st time, if I would have taken it alone at home I would have thought too much, and after that it's total BAD

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